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Generation and Characterization of Amyotrophic Lateral Sclerosis iPS Cells (Stem Cells)

About the Study

Principal Investigator: Jeffrey Rothstein, MD, PhD (Johns Hopkins)
Site-PI: Michael Benatar, MD, PhD

stem-cells-7This is a cross-sectional study in which stems cells are created from skin cells. Skin cells, obtained from a small (3mm) biopsy on the side of the leg, are used to generate induced pleuripotent stem cells (iPS). The goal of this study is to determine whether these stem cells have the expected characteristics of motor neurons and other types of brain cells (astroglia).

Eligibility Criteria
  • Positive for a mutation in the SOD1 gene (affected or pre-symptomatic)
  • Healthy controls
Funding Agencies

NIH_Master_Logo
National Institutes of Health

Collaborators
  • Nicholas Maragakis, MD, PhD (Johns Hopkins)
  • NEALS Investigators
Contact

Research Coordinators

  • Eliana Reyes, B.A.
  • Sumaira Hussain, B.Sc.

Contact Information

  • Email: fals@med.miami.edu
  • Phone: 1-888-413-9315
Links
  • NIH Project Information: Generation and Characterization of Amyotrophic Lateral Sclerosis IPS Cells
Publications
  • Wray S, Houlden H, Morris HR, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PloS one. 2012;7:e43099. [ PubMed Link ]
Presentations and Lectures

Back to Research Studies

Active Research Studies

  • Research Studies (All)
  • Pre-fALS
  • CReATe PGB
  • PRESS-ALS
  • CRiALS Biomarker
  • CRiALS Genetics
  • Neuraltus NP001

Contact Us

By phone:
For familial ALS and general inquiries:
1-888-413-9315
For the CReATe Consortium and related studies:
1-844-837-1031

By email:
fals@miami.edu (For familial ALS inquiries)
projectcreate@miami.edu (For CReATe inquiries)
alsresearch@miami.edu (General inquiries)

Support Our Research

Affiliates

  • CReATe Consortium
  • CReATe Connect
  • The Kessenich Family ALS Center at UM
  • ALS Recovery Fund
  • ALS Association
  • Muscular Dystrophy Association
  • CDC National ALS Registry
  • The Northeastern ALS Consortium
  • Myasthenia Gravis Research Group
Read Our Newsletter

News

  • Biomarker for ALS Disease Progression Identified by the Teams at University of Miami and Flinders University!03/07/2017 - 5:48 pm
  • Brain MedicineDr. Benatar presents promising phase II trial results of Arimoclomol in SOD1 ALS12/09/2016 - 5:02 pm
  • CReATe Consortium Virtual Journal Club12/08/2016 - 3:18 pm
More News
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