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Electrical Impedance Myography as an Outcome Measure in ALS Clinical Trials (EIM)

About the Study

Principal Investigator: Seward Rutkove, MD (Beth Israel Deaconess Medical Center)
Site-PI: Michael Benatar, MD, PhD

eimThis is a longitudinal study designed to assess whether electrical impedance myography (EIM) is a useful measure of disease progression in ALS. EIM is a painless and non-invasive technique that can be used to quantify the biophysical properties of muscle. The study will involve several visits to a study center for serial evaluations. If successful, this study will demonstrate that the use of EIM as an outcome measure would make it possible to complete clinical trials in a shorter period of time and require participation of a small number of people.

Eligibility Criteria
  • Age ≥ 18 years
  • Definite or probable ALS, sporadic or familial
  • MRC grade 3/5 or above in at least one limb
  • FVC > 70% predicted
Funding Agencies

als_assoc_logo
ALS Association

Collaborators
  • Jeremy Shefner, MD, PhD (SUNY Upstate Medical University)
  • Ted Burns, MD (University of Virginia)
  • Jim Caress, MD (Wake Forrest University)
  • Khema Sharma, MD (University of Miami)
  • Nicholas Maragakis, MD, PhD (Johns Hopkins University)
Contact

Research Coordinators

  • Eliana Reyes, B.A.
  • Sumaira Hussain, B.Sc.

Contact Information

  • Email: alsresearch@med.miami.edu
  • Phone: 1-888-413-9315
Links
  • Study Record on ClinicalTrails.gov
Publications
  • Rutkove SB, Caress JB, Cartwright MS, et al. Electrical impedance myography correlates with standard measures of ALS severity. Muscle & Nerve 2014 49(3):441-3. [ PubMed Link ]
  • Rutkove SB, Caress JB, Cartwright MS, et al. Electrical impedance myography as a biomarker to assess ALS progression. Amyotroph Lateral Scler. 2012 Sep;13(5):439-45. [ PubMed Link ]
Presentations and Lectures

Lu D, Rutkove S, Gronka S, Spieker A, Usher S, Wuu J, Andersen P, Benatar M. Electrical impedance myography (EIM) findings in pre-symptomatic SOD1+ subjects. Platform presentation at the 9th Annual Northeast ALS Consortium Meeting, Washington, DC, Oct 27-29, 2010

Electrical Impedance Myography as a Pre-Symptomatic Biomarker of ALS. Poster presentation by Sharon Usher at the 20th International Symposium on ALS/MND Meeting, Berlin, December 2009

Back to Research Studies

Active Research Studies

  • Research Studies (All)
  • Pre-fALS
  • CReATe PGB
  • PRESS-ALS
  • CRiALS Biomarker
  • CRiALS Genetics
  • Neuraltus NP001

Contact Us

By phone:
For familial ALS and general inquiries:
1-888-413-9315
For the CReATe Consortium and related studies:
1-844-837-1031

By email:
fals@miami.edu (For familial ALS inquiries)
projectcreate@miami.edu (For CReATe inquiries)
alsresearch@miami.edu (General inquiries)

Support Our Research

Affiliates

  • CReATe Consortium
  • CReATe Connect
  • The Kessenich Family ALS Center at UM
  • ALS Recovery Fund
  • ALS Association
  • Muscular Dystrophy Association
  • CDC National ALS Registry
  • The Northeastern ALS Consortium
  • Myasthenia Gravis Research Group
Read Our Newsletter

News

  • Biomarker for ALS Disease Progression Identified by the Teams at University of Miami and Flinders University!03/07/2017 - 5:48 pm
  • Brain MedicineDr. Benatar presents promising phase II trial results of Arimoclomol in SOD1 ALS12/09/2016 - 5:02 pm
  • CReATe Consortium Virtual Journal Club12/08/2016 - 3:18 pm
More News
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