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This is a longitudinal study of people who are at risk for developing familial amyotrophic lateral sclerosis (fALS), with the specific goal of improving our understanding of the pre-symptomatic phase of fALS. Participation in the study involves undergoing genetic testing with the option of whether or not to learn genetic test results. Individuals who have undergone genetic testing and can provide documentation of genetic test results may be eligible to participate. Undergoing genetic testing for this study requires that the genetic mutation responsible for ALS in the family be identified.

Eligible participants are invited to travel to the University of Miami every 12-24 months to undergo study procedures (e.g., MRI, neurological examination, environmental risk factors survey, collection of blood and urine samples, cognitive testing, etc.). Participants receive follow up calls every 3-4 months between study visits.