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Filling the gaps in our knowledge of ALS

Advancing ALS therapy and progress toward a cure

Advancing toward a cure

Collaborative and translational research to find and fill the gaps in our knowledge about the causes and treatment of ALS

Welcome to the website for the ALS Research Collaboration (ARC), a clinical/translational research group led by Dr. Michael Benatar and Joanne Wuu at the University of Miami.  Our research program aims to advance ALS therapy development by identifying and filling knowledge gaps that have, in the past, hampered the development of effective treatments.  The complexity of this undertaking requires a breadth of expertise, necessitating our highly inter-disciplinary, broadly collaborative, and seamlessly translational approach to research.  The name of our group – the ALS Research Collaboration – is meant to capture this ethos.  We also see our work as a partnership with the patients and families we serve, whose commitment and engagement have been vital to everything we do.  If you are already working with us or participating in one of our studies, thank you.  If you are in search of information about research or collaborative opportunities, we look forward to hearing from you.

Our Research Focus

Click on each box to see more

Deep Phenotyping

  • Motor
  • Cognitive
  • Phenotype-Genotype

Causes & Modifiers

  • Genetics
  • Environment
  • Gene x Environment

Biomarker Discovery & Validation

  • Biofluid
  • Imaging
  • Electrical
  • Physiological

Novel Data Collection Methods

  • Remote assessments
  • EHR-based

Disease Biology & Drug Discovery

  • iPSC models
  • Drug screening

Clinical Trials

  • Disease modifying
  • Disease prevention

Active Studies

Studies initiated and led by us:

Pre-fALS (Recruiting)
Pre-symptomatic mutation carriers
CRiALS Biomarker (Recruiting)
ALS, ALS related disorders, Controls
CRiALS Genetics (Recruiting)
ALS, ALS related disorders, Family members

CRiALS PRESS-ALS (Active, Not Recruiting)
ALS, Controls

CReATe PGB2 (Recruiting)

CReATe TRIAL READY (Recruiting)
ALS, Controls

CReATe CAPTURE-ALS (Recruiting)
Multidisciplinary ALS Clinic Patients

Studies sponsored by others and in which we play a leadership role:

Biogen ATLAS Trial (Not yet recruiting)
Pre-symptomatic SOD1 mutation carriers

Orphazyme Arimoclomol Phase III Trial (Active, not recruiting)

Studies sponsored by others

Biogen C9 ASO Trial (Recruiting)

Biogen SOD1 ASO “VALOR” Trial (Active, not recruiting)
Healey Platform Trial (Recruiting)

Contact Us

For Pre-fALS and CRiALS studies
For the ATLAS trial
For CReATe Consortium and related studies:
For other research inquiries:

Support Us