Title

Generation and Characterization of Amyotrophic Lateral Sclerosis iPS Cells

Short name

Stem Cells

Principal Investigator

Jeffrey Rothstein, MD, PhD (Johns Hopkins)

Site-PI

Michael Benatar, MD, PhD

Summary

This is a cross-sectional study in which stems cells are created from skin cells.
Skin cells, obtained from a small (3mm) biopsy on the side of the leg, are used to generate induced pleuripotent stem cells (iPS). The goal of this study is to determine whether these stem cells have the expected characteristics of motor neurons and other types of brain cells (astroglia).

Eligibility criteria

• Positive for a mutation in the SOD1 gene (affected or pre-symptomatic)
  
• Healthy controls

Funding agency

National Institutes of Health

Collaborators

Nicholas Maragakis, MD, PhD (Johns Hopkins)
NEALS Investigators

Research Coordinator

Eliana Reyes, B.A.

Contact information

Email:
Phone: 1-888-413-9315

Link(s)

http://projectreporter.nih.gov/project_info_description.cfm?aid=7855283&icde=2326760

http://alsgo.web.officelive.com/default.aspx

Presentations / Publications