(information last updated:
March 9, 2013
This is a prospective observational study of risk factors for anti-retroviral toxic neuropathy in an HIV positive population that is being conducted in Cape Town, South Africa. The goals are to evaluate the importance of risk factors such as prior tuberculosis and anti-tuberculosis therapy, malnutrition and alcohol consumption with respect to the risk of stavudine-induced polyneuropathy.
(status: ongoing, not recruiting)
The Cochrane Collaboration develops systematic reviews and meta-analyses of important medical topics. In 2009 Benatar et al published a review of treatments for ocular myasthenia, which is currently in the process of being updated. We are also in the midst of preparing reviews on the topics of the treatment of orthostatic hypotension, as well as the accuracy of tests for the diagnosis of myasthenia gravis.
(status: ongoing, but not recruiting participants)
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Safety and Efficacy of Dexpramipexole in Subjects With Amyotrophic Lateral Sclerosis.
This is a randomized, double-blind, placebo-controlled study for patients with a clinical diagnosis of familial or sporadic Amyotrophic Lateral Sclerosis (ALS). The purpose of this study is to determine whether dexpramipexole (150 mg twice daily) is safe and effective in the treatment of ALS
Synaptic Activity Following Nerve Injury (SAFNI)
Animal studies have suggested that nerve regeneration following injury is not always accompanied by the re-establishment of complex synaptic circuitry. For this study we are recruiting patients with a history of Bell’s palsy or the Guillain-Barre syndrome. The study involves electrical testing of nerves on at least two occasions to learn more about how nerves recover following injury.
Reference Electrodiagnostic Data
The interpretation of nerve conduction study data requires an appreciation of the range of values that might be encountered in a normal healthy population. In this study, commonly used nerve conduction studies were performed in a large group of healthy volunteers. The data were analyzed using a technique known as quantile regression to develop reference data (sometimes called normative data) for the nerve conduction studies commonly used in routine clinical practice.