Principal Investigators

Dan Drachman, MD, Bryan Traynor, MD, PhD

Site-PI

Michael Benatar, MD, PhD

Summary

The purpose of this project is to conduct a powerful Genome-wide search for genetic factors that are associated with myasthenia gravis (MG), and that are likely to play a role in the disease process. We will use DNA from 1100 MG patients, obtained by collaboration among 14 institutions. Analysis will be carried out in collaboration with the Laboratory of Neurogenetics at the NIH. An improved understanding of the genetic alterations in MG may lead toward a greater understanding of the cause of disease and help to identify specific genetic targets for therapy.

Eligibility criteria

• Ocular or generalized myasthenia gravis
• Antibodies directed against the acetylcholine receptor
• Caucasian

Funding agency

Myasthenia Gravis Foundation of America (MGFA)

Collaborators

Dan Drachman, MD
Bryan Traynor, MD, PhD

Project manager

Julie Steele, RN

Contact information

Email:

Links

Presentations / Publications